Liverpool goalkeeper Alisson has been ruled out of Saturday’s game at Chelsea, live on Sky Sports, head coach Arne Slot has confirmed.

The Brazil international limped off during Liverpool’s 1-0 Champions League defeat at Galatasaray on Tuesday night, with summer signing Giorgi Mamardashvili replacing him for the final 46 minutes as the Reds fell to a second defeat in four days.

“It’s never positive if you go off like this. [Alisson] is definitely not going to play on Saturday,” head coach Arne Slot told Amazon Prime.

In his press conference, he added: “When he sprinted back, he felt something. I cannot tell you [what] because I’m not a physio.

“But normally when a player sprints back, feels something and goes to the floor – which is what they [Galatasaray] by the way did 112 times, getting injured and coming back on the pitch without any pain.

“Our players don’t do this. When my player is on the floor, nine out of 10 times I fear the worst.

“And with the worst, he cannot continue and that’s what happened with Alisson. Normally he will not be able to play Saturday. That’s 99.9 per cent, but I think it’s 100 per cent.”

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Fresh from sitting out Saturday’s defeat at Crystal Palace through suspension, striker Hugo Ekitike was also forced off by injury during the second period on a tough night for the Reds, who had previously won their opening six games of the season in all competitions – though the French forward may yet feature at Stamford Bridge.

“Let’s see how he is for the weekend,” said Slot. “He felt something when he had to reach for the ball. After the game, that’s always the difficult thing with these moments.

“Sometimes you feel it’s not too bad. But when you walk around, it’s something different or have to sprint and have to take a shot on target. He said he couldn’t continue so we had to take him off.”

The defeat marks only the second time Liverpool have lost back-to-back games under Slot, following on from their Champions League exit to PSG and the Carabao Cup final in March last season.

“We’re not so far off last season,” insisted the Reds boss. “We’ve lost twice in a row but the schedule can bring this. Galatasaray away is not an easy game, and we play Chelsea so it’s not an easy run.

“I saw a lot of good things. The way we played, the way we controlled the game. In the second half, there wasn’t a lot of playing time. Their striker was on the floor, substitutes, injuries. The referee blew his whistle exactly after eight minutes.”

Watch Chelsea vs Liverpool live on Sky Sports Premier League from 5pm on Saturday, kick-off 5.30pm.